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Recent Publications

Lew, L.A., Williams, J.S., Stone, J.C., Au, A.K., Pyke K.E., & MacDonald, M.J. Examination of sex-specific participant inclusion in exercise physiology endothelial function research: a systematic review. Frontiers in Sport and Active Living. 2022, 


McGarity-Shipley, E. C., Schmitter, S. M., Williams, J. S., King, T. J., McPhee, I., & Pyke, K. E. The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females. Eur J Appl Physiol. 2021, 121(11):3017-3030. 

Lew, L. A., Liu, K. R., & Pyke, K. E. Reliability of the hyperemic response to passive leg movement in young healthy women. Exp Physiol. 2021, Advance online publication. 

Liu, K. R., Lew, L. A., McGarity-Shipley, E. C., Byrne, A. C., Islam, H., Fenuta, A. M., & Pyke, K. E. Individual variation of follicular phase changes in endothelial function across two menstrual cycles. Exp Physiol. 2021, 106(6), 1389–1400.

Williams JS, Del Giudice M, Gurd BJ, Pyke KE. Reproducible improvement in endothelial function following two separate periods of high-intensity interval training in young men. J Appl Physiol (1985). 2020, 129(4):725-731. 

Wilson, R, Adams, M.L, & Pyke, KE. Inclusion of female participants in cardiovascular research: A case study of Ontario NSERC- funded programs. Applied Physiology, Nutrition, and Metabolism. 2020.

Tremblay JC, Coombs GB, Howe CA, Vizcardo-Galindo G, Figueroa-Mujica RJ, Bermudez D, Tymko MM, Villafuerte FC, Ainslie PN, Pyke KE. Global REACH 2018: Reduced flow-mediated dilation stimulated by sustained increases in shear stress in high-altitude excessive erythrocytosis. Am J Physiol Heart Circ Physiol. 2019, 317(5):H991-H1001.

Reyes LM, Farooq SM, Skow RJ, Busch SA, Pyke KE, Khurana R, Chari RS, Stickland MK, Devolin M, Davidge ST, Sobierajski F, Lugg A, Steinback CD, Davenport MH. Physical Activity in Pregnancy Is Associated with Increased Flow-mediated Dilation. Med Sci Sports Exerc. 2019.

Williams JS, Stimpson TV, Tremblay JC, Fenuta AM, Pyke KE. No impact of acute hyperglycemia on arterial stiffness in the early and late follicular phases of the menstrual cycle in young females. Exp Physiol. 2019. 

King TJ, Pyke KE. Evidence of a limb and shear stress stimulus profile dependent impact of high intensity cycling training on flow-mediated dilation. Appl Physiol Nutr Metab. 2019. 

Tremblay JC, Hoiland RL, Howe CA, Coombs GB, Vizcardo-Galindo GA, Figueroa-Mujíca RJ, Bermudez D, Gibbons TD, Stacey BS, Bailey DM, Tymko MM, MacLeod DB, Gasho C, Villafuerte FC, Pyke KE, Ainslie PN. Global REACH 2018: High blood viscosity and hemoglobin concentration contribute to reduced flow-mediated dilation in high-altitude excessive erythrocytosis. Hypertension. 2019, 73(6): 1327-1335.

Williams JS, Stimpson TV, Tremblay JC, Fenuta AM, Pyke KE. The influence of acute hyperglycaemia on brachial artery flow-mediated dilatation in the early and late follicular phases of the menstrual cycle. Exp Physiol. 2019, 104(6): 957-966. 

Tremblay JC, Grewal AS, Pyke KE. Examining the acute effects of retrograde versus low mean shear rate on flow-mediated dilation. J Appl Physiol (1985). 2019, 126(5): 1335-1342. 

Tremblay JC, Williams JS, Pyke KE. Ramp and step increases in shear stress result in a similar magnitude of brachial artery flow-mediated dilation. Eur J Appl Physiol. 2019, 119(3): 611-619. 

Tremblay JC, Stimpson TV, Pyke KE. Evidence of sex differences in the acute impact of oscillatory shear stress on endothelial function. J Appl Physiol (1985). 2019, 126(2): 314-321.

D'Urzo KA, La Rocque CL, Williams JS, Stuckless TJR, King TJ, Plotnick MD, Gurd BJ, Harkness KL, Pyke KE. The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression. Int J Psychophysiol. 2019, 135: 113-120. 

Tremblay JC, Hoiland RL, Carter HH, Howe CA, Stembridge M, Willie CK, Gasho C, Macleod DB, Pyke KE, Ainsliez PN. UBC-Nepal Expedition: Upper and Lower Limb Conduit Artery Shear Stress and Flow-Mediated Dilation on Ascent to 5050 m in Lowlanders and Sherpa. Am J Physiol Heart Circ Physiol. 2018.

Tremblay JC, Howe CA, Ainslie PN, Pyke KE. UBC-Nepal Expedition: Imposed oscillatory shear stress does not further attenuate flow-medated dilation during acute and sustained hypoxia. Am J Physiol Heart Circ Physiol. 2018.

Tremblay JC, Stimpson TV, Murray KM, Pyke KE. Sitting cross-legged for 30 minutes alters lower limb shear stress pattern but not flow-mediated dilation or arterial stiffness. Applied Physiology Nutrition Metabolism. 2018.

Zelt JT, Jones JH, Hirai DM, King TJ, Berton DC, Pyke KE, O’Donnell DE, Neder JA. Systemic vascular dysfunction is associated with emphysema burden in mild COPD. Respiratory Medicine. 2018, 136: 29-36.

Tremblay JC, Pyke KE. Flow-mediated dilation stimulated by sustained increases in shear stress: a useful tool for assessing endothelial function in humans? Am J Physiol Heart Circ Physiol. 2018, 314(3): H508-H520.

D'Urzo KA, King TJ, Williams JS, Silvester MD, Pyke KE. The impact of menstrual phase on brachial artery flow-mediated dilation during handgrip exercise in healthy premenopausal women. Experimental Physiology. 2017, 103(2): 291-302.

Levac BM, Adams MA, Pyke KE. The impact of an acute oral phosphate load on endothelium dependent and independent brachial artery vasodilation in healthy males. Applied Physiology Nutrition and Metabolism. 2017, 42(12): 1307-1315.

Plotnick MD, D'Urzo KA, Gurd BJ, Pyke KE. The influence of vitamin C on the interaction between acute mental stress and endothelial function. Eur J Appl Physiol. 2017, 117(8): 1657-1688.

Carson IN, Batson MJ, Tranmer JE, Scribbans TD, Gurd BJ, and Pyke KE.  Cardiovascular and cortisol reactivity to acute mental stress in female shift and non-shift workers: A pilot study.  Sage open Nursing May 2017- In Press.


King TJ, Schmitter SM, Pyke KE.  Assessment of flow-mediated dilation in the superficial femoral artery using a sustained shear stress stimulus via calf plantar-flexion exercise.  Exp. Physiol. 2017 Feb. 2 doi 10.1113/EP085980. EPub ahead of print. 


Slattery DJ, Stuckless TJ, King TJ, Pyke KE.  Impaired exercise induced brachial artery flow-mediated dilation in young obese males.  Appl Physiol Nutr Metab. 2016, 41(5), 528-37.

T.J. Stuckless and K.E. Pyke. The impact of cold pressor test on brachial artery handgrip exercise-induced flow-mediated dilation. Vascular Medicine. 2015, 20(5):409-416. See here:


T.J. King, H. Lemke, A.D. Green, D.A. Tripp, V.J. Poitras, B.J. Gurd and K.E. Pyke.  Impaired brachial artery endothelial function in young healthy women following an acute painful stimulus.  European Journal of Applied Physiology.  2015 Mar 1 [epub ahead of print]


D. Montero, G. Walther, C. Diaz-Canestro, K.E. Pyke, J. Padilla.  Microvascular dilator function in athletes: a systematic review and meta-analysis.  Medicine and Science in Sports and Exercise. 2014, Nov. 10,  Epub ahead of print.


V.J. Poitras, D. J. Slattery, B.J. Gurd and K.E.Pyke.  Evidence that meal fat content does not impact hemodynamic reactivity to or recovery from repeated mental stress tasks.  Applied Physiology Nutrition and Metabolism.  2014, 39(11): 1314- 21.


D. Montero, J. Padilla, C. Diaz-Cañestro, D. M. Muris, K. E. Pyke, P. Obert, G. Walther.  Flow-mediated dilation in athletes: influence of aging.  Medicine and Science in Sports and Exercise.  2014, 46(11): 2148-58. 


I.C. Szijgyarto, V.J. Poitras, B.J. Gurd and K.E. Pyke.  (2014). Acute psychological and physical stress transiently enhances brachial artery flow mediated dilation stimulated by exercise induced increases in shear stress.Applied Physiology, Nutrition and Metabolism.  39(8):927-307.


J.Ku, A. McEvoy, K.E. Pyke. (2014) Can a Combination of Handgrip Exercise and Prolonged Forearm Occlusion Elicit a Maximal Brachial Artery FMD response?  European Journal of Applied Physiology.  2014, 114(6):1297-306.


V.J. Poitras, D.J. Slattery, B.M Levac, S. Fergus, B.J. Gurd and K.E. Pyke. (2014).  The influence of fat consumption and repeated mental stress on brachial artery flow mediated vasodilation: a preliminary study.Experimental Physiology. 2014, 99(4):715-28.


I.C. Szijgyarto, T.J. King, J. Ku, V.J. Poitras, B.J. Gurd, K.E. Pyke. (2013).  The impact of acute mental stress on brachial artery flow mediated dilation differs when shear stress is elevated by reactive hyperemia vs. handgrip exercise.  Applied Physiology, Nutirtion, and Metabolism.  38(5):498-506.


V.J. Poitras and K.E. Pyke. (2013). The impact of acute mental stress on vascular endothelial function:  Magnitude, mechanisms and importance.  International Journal of Psychophysiology. 88(2): 124-35.


B.B. Fundlay, P. Gupta, I.C. Szijgyarto and K.E. Pyke. (2013).  Impaired brachial artery flow-mediated vasodilation in response to handgrip exercise induced increases in shear stress in young smokers.  Vascular Medicine. 18(2):63-71.


T.J. King, D.J. Slattery, and K.E. Pyke. (2013).  The impact of handgrip exercise duty cycle on brachial artery flow-mediated dilation.  European Journal of Applied Physiology. 113(7):1849-58.


F. Jazuli and K.E. Pyke (2011).  The impact of baseline artery diameter on flow-mediated vasodilation: A comparison of brachial and radial artery responses to matched levels of shear stress.  American Journal of Physiology.  301(4): H1667-77


K.E. Pyke and F. Jazuli (2011). Impact of repeated increases in shear stress via reactive hyperemia and handgrip exercise: No evidence of systematic changes in brachial artery FMD.  American Journal of Physiology 300 (3): H1078-1089


D. H.J. Thijssen, M.A. Black, K. E. Pyke, J. Padilla, G. Atkinson, R. A. Harris, B. Parker, M. E. Widlansky, M. E. Tschakovsky, D.J.Green. (2011)  Assessment of flow mediated dilation (FMD) in humans: A methodological and physiological guideline.  American Journal of Physiology 300(1): H2-12.  


K.E.Pyke.  Are we still on the fence or can we open the gate?  Evidence that QRS-gating in FMD analysis is not essential.  Journal of Applied Physiology.  109(4): 945-6     


K.E. Pyke, Green, D., Weisbrond, C, Best, M. Dembo, L., O'Driscoll, G. and Tschakovsky, M.E. (2010).  Nitric oxide is not obligatory for radial artery flow-mediated dilation following release of 5 or 10 min of distal occlusion.  American Journal of Physiology, Heart and Circulatory Physiology. 298(1):H119-26


K.E.Pyke, J.A.Hartnett, and M.E.Tschakovsy. (2008). Are the dynamic response characteristics of brachial artery FMD sensitive to the magnitude of the increase in SS? Journal of Applied Physiology. 105(1): 282-92.


K.E.Pyke, V.Poitras and M.E.Tschakovsky. (2008). Brachial artery flow mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus. American Journal of Physiology, Heart and Circulatory Physiology. 294(6): H2669-79.

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